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Who Responds Best to PRP Injections for Knee Arthritis? | Dr. Jeffrey Peng MD
Medically reviewed by Dr. Jeffrey Peng, MD — Board-Certified Sports Medicine Physician Published: February 26, 2026 | Last Updated: February 26, 2026 Platelet-rich plasma (PRP) injections have become one of the most promising non-surgical treatments for knee osteoarthritis. However, not every patient experiences the same degree of improvement. In my practice, I have treated thousands of patients with PRP, and while the majority respond well, there are clear patterns in who b
Jeffrey Peng MD
Feb 264 min read


Best Knee Arthritis Injections Ranked: PRP, Cortisone, Hyaluronic Acid, and Stem Cells | Dr. Jeffrey Peng MD
Board-certified sports medicine physician Dr. Jeffrey Peng ranks knee arthritis injections — PRP, hyaluronic acid, cortisone, and stem cells — based on the latest 2025 clinical evidence, safety data, and real-world outcomes.
Jeffrey Peng MD
Feb 266 min read


3-Step Evidence-Based Protocol to Eliminate Knee Arthritis Pain
Osteoarthritis is now recognized as a metabolic disease. Learn the 3-step evidence-based protocol — metabolic health optimization, PRP injection therapy, and targeted exercise — to reduce knee arthritis pain and restore mobility.
Jeffrey Peng MD
Feb 258 min read


Can You Play Sports After a Knee Replacement? A New Study Tracked 1,800 Athletes
A brand new study out of the Cleveland Clinic just tracked nearly 1,800 athletes through their knee replacement and recovery — and the results challenge a lot of what patients are being told. Only 53% made it back to sports within a year. But the ones who did? Most were back in just 12 weeks. So what separates the people who return from the ones who don't? As a sports medicine doctor in the San Francisco Bay Area, I treat patients with knee arthritis every week. And this que
Jeffrey Peng MD
Feb 214 min read


The Biggest Lies About Knee Osteoarthritis You've Been Told!
What if I told you that much of what you know about knee osteoarthritis is completely wrong? In this video, we'll uncover the truth...
Jeffrey Peng MD
May 30, 20248 min read


Meniscus Tear Treatments That ACTUALLY Work: The In-Depth Truth You Need to Know
There is significant controversy and debate within the medical community about the most effective treatment approaches for meniscus...
Jeffrey Peng MD
Apr 28, 202418 min read


Knee Arthritis Treatments That ACTUALLY Work: The In-Depth Truth You Need to Know
Knee arthritis treatment is complex and to make matters worse, there is a lot of misinformation from online sources and medical...
Jeffrey Peng MD
Apr 22, 202441 min read


The Best Exercises to Treat Patellofemoral Pain & Chondromalacia
What is patellofemoral pain syndrome and chondromalacia patella? Patellofemoral pain syndrome describes pain and discomfort around or...
Jeffrey Peng MD
Feb 24, 20244 min read


IT Band Syndrome Treatment & Exercises
What is IT band syndrome? The IT band extends from the hip to the outer part of the knee. IT band syndrome occurs when this band becomes...
Jeffrey Peng MD
Feb 24, 20243 min read


Are Genicular Nerve Blocks the Answer to Your Knee Pain?
If you are seeking a breakthrough treatment in managing knee osteoarthritis pain, then you are in the right place. Today we’re going to...
Jeffrey Peng MD
Dec 19, 20234 min read


A Beginner’s Guide to Baker’s Cyst Treatment
A Baker's cyst is a collection of fluid in the back of the knee and can cause pain and discomfort with bending the knee. So what is it...
Jeffrey Peng MD
Nov 6, 20233 min read


Which Knee Support & Brace for Arthritis Pain?
Do you suffer from knee pain due to arthritis? If so, you may have been recommended to try a knee support or knee brace to relieve your...
Jeffrey Peng MD
Oct 1, 20235 min read


Collagen Type 2 for Joint and Knee Pain
Collagen supplements are advertised to help reduce joint pain, improve stiffness, and slow down the progression of arthritis. But do they ACTUALLY work? 🤔 Let’s look at what some recent clinical trials say. 👇 Collagen is a type of protein that is naturally found in the body and is a key component of cartilage. Articular cartilage is what helps pad and protect our bones. Osteoarthritis by definition is caused by the loss of articular cartilage. The theory is that taking coll
Jeffrey Peng MD
Sep 20, 20234 min read


Top 7 Signs & Symptoms You Have Knee Arthritis
These are the top 7 signs and symptoms of knee arthritis. I’m going to go over each one of these symptoms in detail to help you understand what’s going on inside your knee. I’m also going to give you the one treatment that everyone should be doing to alleviate pain, maintain your independence and ability to perform daily activities, and even slow down the progression of arthritis. Knee osteoarthritis is characterized by the progressive deterioration and loss of cartilage insi
Jeffrey Peng MD
Aug 27, 20235 min read


Platelet Rich Plasma (PRP) Injections Slow Down Knee Arthritis
Platelet rich plasma treatments are extremely effective at decreasing pain and symptoms related to symptomatic knee osteoarthritis. But do PRP injections help slow down the progression of knee arthritis? That’s what the authors of this randomized controlled trial tried to answer. Let’s look at what they found. I’m really excited to review this clinical trial with you because it was extremely well designed and showed some of the amazing potential PRP has when used to treat art
Jeffrey Peng MD
Aug 22, 20236 min read


Arthroscopic Knee Surgery or Platelet Rich Plasma (PRP) injection for Knee Arthritis?
So which one is better? Arthroscopic knee surgery or PRP injection for the treatment of symptomatic knee osteoarthritis? Head to head trials comparing PRP to placebo, PRP to hyaluronic acid, and PRP to cortisone injections all show that PRP has much better and much more sunstained symptom relief when used to treat arthritis. But what about surgery? Let’s look at this randomized controlled trial to find out more. Knee osteoarthritis results in significant pain and disability.
Jeffrey Peng MD
Aug 21, 20234 min read


Platelet Rich Plasma (PRP) + Meniscus Repair Surgery
There is considerable debate within the orthopedic community about what the best treatment options are for a meniscus tear. What’s becoming clear is that cutting out the meniscus should really be seen as a last resort. But what about repairing the meniscus? Newer and better techniques for meniscus repair surgery have been shown to have lower failure rates. And with advances in orthobiologics and cellular therapy, many providers are excited about augmenting these repairs with
Jeffrey Peng MD
Aug 19, 20236 min read


Jeffrey Peng MD
Sep 8, 20220 min read


Jeffrey Peng MD
May 15, 20220 min read


Jeffrey Peng MD
Mar 20, 20220 min read
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