Written by Dr. Jeffrey Peng, MD — Board-Certified Sports Medicine Physician Published: March 1, 2026 | Last Updated: March 1, 2026 Platelet-rich plasma (PRP) injections are increasingly marketed as a natural, regenerative treatment for sciatica and low back pain — promising to reduce inflammation, promote tissue healing, and provide lasting relief without the downsides of steroids. But does the science actually support these claims? A brand-new systematic review and meta-ana