Written by Dr. Jeffrey Peng, MD — Board-Certified Sports Medicine Physician Published: March 1, 2026 | Last Updated: March 1, 2026 One of the most common questions I hear from patients considering platelet-rich plasma therapy is: "Do PRP injections hurt?" Most people assume it is just another quick, relatively painless shot. And while that is often true during the procedure itself, the real surprise comes a few hours later — and it can catch people completely off guard. In m