By Dr. Jeffrey Peng, MD · Published May 3, 2026 · 7 min read Watch the Full Video The data on platelet-rich plasma (PRP) for knee osteoarthritis is now overwhelming. PRP outperforms cortisone, hyaluronic acid, and saline placebo across multiple meta-analyses, and it is widely considered the single best injection we have for addressing pain, improving function, and even slowing the progression of knee arthritis. But there is a catch most patients — and even most physicians — d