NSAIDs and even low-dose aspirin can blunt the growth factors that make PRP work. Here’s exactly which medications to stop — and for how long — before and after your injection.

By Dr. Jeffrey Peng, MD · Published March 5, 2026 · 6 min read Watch the Full Video Over-the-counter pain relievers such as ibuprofen and naproxen are among the most commonly recommended medications for knee osteoarthritis . They can take the edge off a painful flare, but they come with a long list of potential side effects — gastrointestinal bleeding, kidney damage, elevated blood pressure, and cardiovascular complications — risks that climb steeply in the older adults who