By Dr. Jeffrey Peng, MD · Published March 5, 2026 · 7 min read Watch the Full Video Glucosamine and chondroitin are among the most widely used dietary supplements for joint pain and arthritis. Walk into any pharmacy, and you will find shelves stocked with combination formulas promising relief. But despite decades of use, significant debate remains over whether these supplements actually deliver meaningful clinical benefits. A large 2018 systematic review published in the Br

Collagen is heavily marketed for arthritis. Here’s what the clinical trials actually show — and why I still recommend other supplements first.

By Dr. Jeffrey Peng, MD · Published March 5, 2025 · 7 min read Watch the Full Video Collagen supplements are widely marketed for reducing joint pain, improving stiffness, and slowing the progression of arthritis. Collagen is a naturally occurring protein and a major structural component of cartilage — the tissue that cushions and protects our joints. Osteoarthritis is fundamentally a disease of cartilage loss, so the idea behind collagen supplementation is straightforward:

Most joint supplements don’t work. Here’s the evidence-based ranking of what actually helps arthritis pain — and what you can skip.