Dr. Jeffrey Peng, MD · Published March 5, 2025 · 7 min read Watch the Full Video Omega-3 fatty acids and fish oil supplements are among the most popular over-the-counter options people reach for when dealing with arthritis and joint pain. With their well-established role in cardiovascular and kidney health, many patients ask whether these same anti-inflammatory benefits extend to symptomatic knee osteoarthritis . The short answer? The evidence is mixed — and the clinical ef