By Dr. Jeffrey Peng, MD · Published March 6, 2026 · 5 min read Watch the Full Video Dextrose prolotherapy is one of the oldest regenerative injection therapies still in use today, yet most patients have never heard of it. The concept is simple: inject a concentrated sugar solution into or around a damaged joint to trigger the body’s natural healing response. But does the science actually support this approach for knee arthritis ? In this post, we review the clinical trial ev