By Dr. Jeffrey Peng, MD · Published March 5, 2026 · 7 min read Watch the Full Video Glucosamine and chondroitin are among the most widely used dietary supplements for joint pain and arthritis. Walk into any pharmacy, and you will find shelves stocked with combination formulas promising relief. But despite decades of use, significant debate remains over whether these supplements actually deliver meaningful clinical benefits. A large 2018 systematic review published in the Br