Written by Dr. Jeffrey Peng, MD — Board-Certified Sports Medicine Physician Published: March 4, 2026 | Last Updated: March 4, 2026 Knee cartilage lesions — including chondromalacia and osteochondral defects — have long been considered irreversible. Once cartilage wears down or detaches, the conventional wisdom has been that it simply cannot regenerate on its own. However, emerging evidence suggests that platelet-rich plasma (PRP) injections may not only reduce pain and impr